Phoslactomycin b
WebUsing a PLM-producing strain, Streptomyces sp. HK-803, we have carried out an incorporation study of [7-13 C]CHC, which suggests that PLM-A and PLM C–F are derived from a hydroxylation of PLM-B. The entire 75 kb of … WebSep 1, 2005 · Phoslactomycin B was produced from a NP1 mutant strain of Streptomyces sp. HK-803 and purified by semi-preparative HPLC. A study of PLM-B degradation was carried out in the pH range of 2∼10 at ...
Phoslactomycin b
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WebAn efficient and highly convergent total synthesis of Leustroducsin B was achieved in 17 longest linear and 39 total steps by disconnecting the molecule into three fragments having similar levels of complexity. WebPhoslactomycins (PLMs) (also called phosphazomycins or phospholines) and leustroducsins ( Fig. 1) are structurally related natural products. The …
WebAug 5, 2013 · Phoslactomycins [10] [11] [12] [13] and leustroducsins [14,15] are polyketides that possess α,β-unsaturated δ-lactone and cyclohexane moieties at both ends, which are tethered through a highly... WebFeb 2, 2007 · The majority of modular polyketide synthase (PKS) systems which generate unsaturated products do so with trans double bonds. Phoslactomycin B (PLM B) presents a class of antitumor and antiviral natural polyketide products that have unique structural features, including a linear unsaturated backbone with one trans and three cis double …
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WebJun 12, 2009 · The active substance was identified as deamino-hydroxy-phoslactomycin B (HPLM) by mass spectrometry, and synthesized HPLM also induced the differentiation of HL-60 cells. HPLM showed greater inhibition of protein phosphatase 2A (PP2A) activity than phoslactomycin B (PLMB); however, PLMB and okadaic acid did not induce … crystal palace v everton live streamWebJul 1, 2008 · Phoslactomycin B (PLM-B), a potent and selective inhibitor of serine threonine phosphatase is of interest for its antitumor, antifungal and antiviral activity. crystal palace versus southamptonWebNov 10, 2012 · Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster J. Biol. Chem. (2003) B. Ostash et al. A streamlined metabolic pathway for the biosynthesis of moenomycin A Chem. Biol. (2007) O. Lazos dye chestnut hairWebPhoslactomycin is a natural product from the isolation of Streptomyces species. This is an inhibitor of the protein serine/threonine phosphatase which is the protein phosphate 2A . … dye chest protectorWebMay 5, 2006 · The implicated intermediate in the biosynthesis of phospholine (phoslactomycin B, see picture), namely its deamino precursor, as well as phospholine itself are synthesized. The phoslactomycins show antitumor, antibacterial, and antifungal activities, however, it is not yet known which part of the skeleton contributes to the … dye chestnut brown hairWebPhoslactomycin B (PLM-B), a potent and selective inhibitor of serine threonine phosphatase is of interest for its antitumor, antifungal and antiviral activity. Described herein is an … crystal palace v everton 1980/81Web(+)-Phoslactomycin B was synthesized by a highly enantio- and stereoselective approach involving asymmetric pentenylation, Suzuki−Miyaura coupling, ring-closing metathesis, … crystal palace v everton prediction