WebMar 24, 2024 · Both in vivo and in vitro studies indicate that FGF1 ∆HBS exerted these beneficial effects by markedly reducing mitochondrial fragmentation, reactive oxygen species (ROS) generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5' AMP-activated protein kinase (AMPK)/Nur77 … WebSep 27, 2024 · fibroblast growth factor 1; nonalcoholic fatty liver disease; oxidative stress; AMP-activated protein kinase; nuclear factor erythroid 2-related factor 2 Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder and is strongly associated with type 2 diabetes (T2D).
"A novel fibroblast growth factor 1 variant reverses nonalcoholic …
WebFeb 11, 2024 · Among them, expression of the FGF1 gene was recorded in interstitial and sertoli cells of testes, promoting germ-cell proliferation and differentiation. In sum, the obtained results enabled systematic and functional characterization of FGF genes in S. schlegelii, laying a foundation for further studies on FGF genes in other large teleost … WebJul 14, 2024 · FGF21 is an endocrine hormone that signals via a receptor complex consisting of FGF1 receptor and coreceptor βKlotho. FGF21 is expressed in multiple peripheral tissues, including liver, skeletal muscle, … nigel victor houston australia
The role of the fibroblast growth factor family in bone-related diseases
WebMar 2, 2024 · Hepatic fibrosis can be considered as wound healing response upon chronic liver injury that can progress to cirrhosis, the major risk factor for hepatocellular … WebJun 13, 2013 · FGF1 has been implicated in a range of physiological processes, including development, wound healing, and cardiovascular changes [ 3 ]. Surprisingly, FGF1 knockout mice are viable and normal under standard laboratory conditions, the physiological role of FGF1 is not clear [ 25 ]. WebApr 24, 2012 · Now, scientists have identified the linchpin of fat metabolism, a protein known as fibroblast growth factor 1 (FGF1), which may open new avenues in the treatment of diabetes. Humans are built to ... npg computational materials