WebNov 15, 2024 · STP938, a highly selective CTPS1 inhibitor, demonstrates single agent activity in vitro and in vivo, and shows strong synergy with the approved BCL2 inhibitor venetoclax. STP938 will enter clinical development for relapsed refractory B and T cell … WebMar 1, 2024 · The metabolic enzyme CTP synthase (CTPS) can form filamentous structures named cytoophidia in numerous types of cells, including follicle cells. However, the regulation of cytoophidium assembly...
Inhibition of CTP synthase from - ScienceDirect
WebSTP938 is an orally bioavailable, small molecular weight, selective inhibitor of CTPS1 developed by Step Pharma. Objectives: To demonstrate the in vitro effects of CTPS1 inhibition on T and B cell proliferation and the therapeutic potential of STP938 using in vivo models of disease. WebSep 1, 2024 · Cytidine 5'‐triphosphate synthetase (CTPS) is known to be a central enzyme in the de novo synthesis of CTP. We have recently demonstrated that a deficiency in CTPS1 is associated with an impaired... chiropractic talking points
The metabolic enzyme CTP synthase forms cytoskeletal filaments
WebJan 20, 2024 · The first identified CTPS inhibitor cyclopentenyl cytosine (CPEC) showed initially promising anti-tumor activity in human colon carcinoma, pediatric acute … WebDriven by our deep understanding of CTPS1 biology and nucleotide synthesis, Step Pharma has discovered STP938, a first-in-class, highly selective, orally bioavailable CTPS1 … WebOct 5, 2024 · Selective inhibition of the proliferative CTPS1 isoform is therefore desirable in the treatment of immune disorders and lymphocyte cancers, but little is known about … graphics card displayport